Position 9-substituted adenine derivatives great phosphodiesterase type-4 inhibitors.

Immunotherapy Weekly | June 25, 2003 | Copyright

2003 JUN 25 - (NewsRx.com & NewsRx.net) -- Position 9-substituted adenine derivatives are potent, highly selective phosphodiesterase type-4 inhibitors that may be useful in treatment of inflammation, asthma, or autoimmune disorders.

"Adenine derivatives substituted in position 9 have been demonstrated to have potent cyclic nucleotide phosphodiesterase (PDE) inhibition properties with high selectivity toward PDE-4. Starting from our initial lead compound 9-(2-fluorobenzyl)-N-6(-methyl-2-trifluoromethyladenine (4, NCS613), we designed and synthesized a new series of ...

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