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Sir John Robert Vane

The Columbia Encyclopedia, Sixth Edition | 2008 | Copyright

Sir John Robert Vane 1927-2004, British pharmacologist, Ph.D. Oxford, 1953. With B. I. Samuelsson and Sune K. Bergström , Vane was awarded the 1982 Nobel Prize in Physiology or Medicine. The trio won the prize for their identification and description of various compounds known as prostaglandins , which affect such functions as blood pressure and body temperature. Vane's work helped explain the effects on the body of aspirin , the world's most widely used drug and also contributed to the discovery and development of cox-1 and cox-2 inhibitors (see nonsteroidal anti-inflammatory drug ). He was knighted in 1984.

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