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Cellular Aging
Encyclopedia entry from: Encyclopedia of Aging
...model of human aging. The hallmark of senescence is the inability of cells to replicate...believed to contribute to the process of senescence. The appearance of growth inhibitors...expressed. The factors controlling senescence are dominant over those that control...
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Theories of Biological Aging: Programmed Aging
Encyclopedia entry from: Encyclopedia of Aging
...repair themselves, leading to cell senescence and death. Other investigators felt...The proposed mechanisms of programmed senescence included the existence of a life-span...Further refinement of the programmed senescence theory was developed by Bernard Strehler...
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Cellular Aging: Cell Death
Encyclopedia entry from: Encyclopedia of Aging
...Perhaps the best known of these is cellular senescence. Cellular senescence First identified in the late 1960s by Leonard Hayflick and his collaborators, the term cellular senescence refers to the fact that normal, nonmalignant...
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Physiological Changes, Fibroblast Cells
Encyclopedia entry from: Encyclopedia of Aging
...x2014; or, more accurately, cellular senescence — in culture. In the early...accurately, been termed replicative senescence. Since the 1960s, many cell types...causes and consequences of replicative senescence comes from studies of human fibroblasts...
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Accelerated Aging: Animal Models
Encyclopedia entry from: Encyclopedia of Aging
...to study accelerated aging, accelerated senescence, premature aging, premature senescence, and progeria-like syndromes. These models...mortality suggests that the rate of organismic senescence is not accelerated by life-shortening radiation...
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ageing
Book article from: The Oxford Companion to the Body
...from complete. Cell replicative senescence Much research on cell ageing...phenomenon of cell replicative senescence. Cells from many tissues can...suggest that cell replicative senescence may be primarily an anti-cancer...
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euthanasia
Book article from: The Oxford Companion to the Body
...Christian medicine would surpass pagan science by the conquest of senescence. Francis Bacon and the later philosophers of the Enlightenment...interest in prolongevity. Benjamin Franklin boldly declared senescence to be not a natural process but a ‘disease...
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Genetics: Gender
Encyclopedia entry from: Encyclopedia of Aging
...greater risk of death from heart disease. At reproductive senescence, with involution of the gonads, the protective effects of...consequence of the cessation of estrogen production at reproductive senescence is the gradual demineralization of bone, resulting in osteoporosis...
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Immunology: Animal Models
Encyclopedia entry from: Encyclopedia of Aging
...the progressive increase begins with the onset of immune senescence, i.e., dimunution of T lymphocyte function accompanying...These observations indicate that the onset of both immune senescence and skin aging are not dependent on time, but are genetically...
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Childlessness
Encyclopedia entry from: International Encyclopedia of the Social Sciences
...in vitro fertilization. The second cause of infertility is senescence-related (i.e., due to aging). From the time women...rate with increasing age. ART can overcome some of these senescence-related problems, but technologies still cannot overcome...
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